منابع مشابه
A new gene in A. rubens: A sea star Ig kappa gene
The sea star Asterias rubens reacts specifically to the antigen:HRP (horse-radish peroxydase) and produces an antibody anti-HRP. We previously identified a candidate Ig kappa gene corresponding to this manuscript. We show now the gene referred to as: "sea star Ig kappa gene in its specificity".
متن کاملThe Downstream Transcriptional Enhancer, Ed, positively regulates mouse Ig kappa gene expression and somatic hypermutation.
The mouse Igkappa locus has three known transcriptional enhancers: the matrix association region/intronic enhancer, the 3' enhancer (E3'), and the further downstream enhancer (Ed). Previous studies have shown that both matrix association region/intronic and E3' enhancers are required for maximal gene rearrangement of the locus, and that E3' is also required for maximal expression and somatic hy...
متن کاملImmature surface Ig+ B cells can continue to rearrange kappa and lambda L chain gene loci
Pro and pre B cells possess the long-term capacity to proliferate in vitro on stromal cells and interleukin 7 (IL-7) and can differentiate to surface immunoglobulin (sIg+) cells upon removal of IL-7 from the cultures. A key event in this differentiation is the extensive cell loss due to apoptosis. Because the proto-oncogene bcl-2 can promote cell survival, we established pre-B cell lines from E...
متن کاملMyélome à Ig D Kappa révélé par des lombosciatiques bilatérales
Le myélome multiple à Ig D est une entité rare (1 à 3 % des myélomes multiples), caractérisée par sa sévérité clinique et son mauvais pronostic. Le sous-type à Ig D Kappa n'en représente que 10 à 30 %. Nous rapportons l'observation d'un patient âgé de 70 ans, sans antécédents pathologiques, hospitalisé pour des lombosciatiques L3 bilatérales, hyperalgiques, d'allure inflammatoire et rebelles au...
متن کاملImmune Properties Corroborated by A. Rubens Sea Star Igkappa Gene
The general idea that emerged from the experiments, made in our laboratoires, was that Echinodermata, as exemplified by sea stars: Asterina gibbosa and Asterias Rubens, possessed an immune system, with B cell lymphocytes, able to mount cellular and humoral-specific responses, after stimulation with a foreign antigen [1]. Asterias Rubens produced ‘‘An antibody’’ anti HRP after injections to HRP,...
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ژورنال
عنوان ژورنال: Cell & Cellular Life Sciences Journal
سال: 2017
ISSN: 2578-4811
DOI: 10.23880/cclsj-16000116